In particular recurrence rates are clinically and administratively important but add enormously to trial costs.
In our results, CNNLOH was observed across tumour types with particular recurrence in regions of known key tumour suppressor genes such as PTEN and TP53.
We correlate significant tumour-specific changes with clinicopathological characteristics, in particular, recurrence and survival, opening directions for future biomarker and mechanistic studies in OSCC.
In particular, recurrence and/or disease progression despite chemotherapy and/or successful antiretroviral therapy are not uncommon (Maurer et al, 2007; Bower et al, 2008; Sullivan et al, 2009), suggesting that immune reconstitution alone may not be the unique mechanism able to influence KS clinical outcome (Pellet et al, 2001).
Such studies, when designed, analyzed, and interpreted correctly, can help distinguish genetic from environmental causes that portend increased recurrence of a particular pregnancy complication (eg, recurrence of gestational diabetes) or a perinatal outcome (eg, recurrence of preterm birth or preeclampsia).
where c > 0. Obviously, the recurrence equations (9) and (10) can be retrieved as a particular case ofthe recurrence equation (8).
In particular, recurrences in distant organs or distant lymph nodes (distant recurrences) have a critical impact on the prognosis of CRC.
A particular concern is recurrence of infection which occurs in approximately 25% of patients [ 5], with each recurrent episode associated with increased risk of further recurrence and disease severity [ 6].
Clearly, the preceding Divide and Conquer recurrence equation can be retrieved as a particular case of the recurrence equation (5).
Although this proposed system of classification clearly requires further validation in other series, it may potentially aid in the recognition of more clinically relevant groups of patients with DCIS, namely women with low-risk disease who may not require further adjuvant therapy to the breast and a group with a particular high risk of recurrence who may benefit from maximal local therapy.
