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That a patient's precise response to a particular dosage of chemotherapy remains difficult to discern was glumly acknowledged by Dr. Verda Hunter, the oncologist who first detected Courtney's scheme.
At the time the discoveries embodied in the patents were made, scientists already understood that the levels in a patient's blood of certain metabolites, including, in particular, 6-thioguanine and its nucleotides (6-TG) and 6-methyl-mercaptopurine (6-MMP), were correlated with the likelihood that a particular dosage of a thiopurine drug could cause harm or prove ineffective.
A particular dosage for eosinophilic granulomas cannot be recommended.
Finding a different form to develop an improved drug product required an understanding of the properties needed for a particular dosage form and thorough characterization of various forms.
[58] carried out a systematic review to determine the midterm effectiveness of ESWT, but due to the variability of treatment and reliability of the available studies, they were not able to come to a conclusion regarding a particular dosage of treatment.
The U.S. government often gives a single drug maker a period of exclusivity on a particular dosage of a new generic drug, a policy which has allowed Barr Labs to reap a windfall from a generic Prozac that is cheaper than the branded version made by Indianapolis-based Eli Lilly, but not nearly as cheap as other generics that will go on sale later this year.
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When one out of three patients at a particular dose level during TC 1 experienced a DLT, an additional three patients were enrolled onto this dosage group.
The calculated p-values shown represent level of significance (** p < 0.01; *** p < 0.001) of a given PDL at a particular irradiation dosage relative to the earliest PDL at the same irradiation dosage.
Currently doctors rely on occasional blood tests to assess a cancer patient's tolerance of a particular treatment dosage.
In a tiny 30-patient trial, 8 patients who got the same particular dosage all seemed to improve after four months; patients who got greater or lesser dosages didn't do better.
If sufficient sample size exists in particularly large patient samples, an additional approach might be to restrict the analysis to patients only receiving one particular dosage of the medication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com