Sentence examples for a partial destabilization of from inspiring English sources

This finding suggests that in the absence of the intact C2 24 disulfide bond, there is an increased tendency of the Ig domain to form higher order and probably nonspecific oligomers, perhaps reflecting a partial destabilization of structure.

Structural modeling and energetic analysis of the mutational hotspots have also suggested a common molecular mechanism of kinase activation by cancer mutations, which may be determined by a combined effect of the partial destabilization of the inactive state and a concomitant stabilization of the active-like form of the enzyme.

Thus, loss of HDAC1 in the absence of elevated HDAC2 leads to strongly reduced deacetylase activity and partial destabilization of HDAC1/HDAC2 repressor complexes.

The idea is attractive because the channel must prepare to open toward the lumen or the membrane, requiring at least partial destabilization of the contacts that prevent access to these compartments.

MgADP-fluoroaluminate or MgADP-fluoroscandium failed to inhibit αT349D and αT349Q mutants, indicating strong destabilization of the transition state, while partial inhibition occurred in αT349A, and βArg-182, αT349R, and double mutant αT349R/βR182A, representative of the partial destabilization of the transition state.

Similar partial destabilization of the acceptor stem of other tRNA species is recognized as the degradation flag by CCA transferase to introduce an unusual CCACCA sequence instead of the normal CCA to the 3′-end of the tRNAs (Wilusz et al., 2011).

Results of this study showed that drug complexation altered protein conformation by major reduction of α-helix and increase of turn structure which is indicative of a partial protein destabilization.

At lower dilutions (partial destabilization), the deposited material possesses a small net negative charge; higher dilutions resulted in a positively charged deposit.

A total or partial meniscectomy produces a great destabilization of the joint, thus leading to a rapid degeneration and a more severe pathology (McDermott & Amis 2006).

Recently, a partial knockdown of PfCDPK1 was achieved by introducing a destabilization domain into the protein without an obvious phenotype (15).

Lysosome destabilization can lead to necrotic or autophagic cell death and when the lysosomal disruption leads to a partial release of the lysosomal content in the cell cytoplasm, it can trigger apoptosis or necroptosis through the activation of mitochondrial pathway.