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The interactions occur between the N-terminal α helix of EF1-2, the loop connecting EF1 and EF2 intercalates between α helices 2 and 3 of SR4, whereas the C-terminal α helix of EF1-2 lins in a parallel orientation on the third α helix 3 of SR4.
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Moreover, the functionalization of the substrate surface triggered a parallel orientation of cells when cultured on it.
Hence, this data can only be explained by a parallel orientation of the helices.
The crystal structures of the SYNZIP1 SYNZIP2 and SYNZIP5 SYNZIP6 pairs confirm a parallel orientation for these complexes, so these were used as parallel controls.
A copy of the autopsy report obtained by HuffPost states "six superficial incised wounds" in a "parallel orientation," were observed on Himelrick's left forearm.
PolDom monomers face one another, with the bound duplexes (T/D) appearing in a near parallel orientation on the top of the complex.
Our focus on Aβ-derived peptides may miss structural contributions like hydrogen-bond ladders, as, for example, for in-parallel stacked Asn or Gln, which also greatly enhances the stability of a parallel orientation.
The observed preference toward a parallel orientation would facilitate processive binding, although we can identify no clear mechanism as to the origins of the preferential parallel orientation.
Stacking of chemically similar charged residues in a parallel orientation creates electrostatic repulsion.
As can be seen from Table 1, there is a general trend: longer segments prefer a parallel orientation.
However, dimer modeling by introducing an interchain disulfide, reported at Cys 1201, was not feasible in a parallel orientation.
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