Exact(2)
A three-tiered approach was taken to develop a panel of type I interferon-inducible mRNAs as potential PD markers for sifalimumab in SLE.
We implemented a three-tiered approach to identify a panel of type I interferon-inducible mRNAs to be used as potential pharmacodynamic biomarkers to aid dose selection in clinical trials of sifalimumab, an anti-IFNα monoclonal antibody under development for the treatment of SLE.
Similar(58)
Isolates were serotyped by slide agglutination according to the International Antigenic Typing Scheme IATSS) for P. aeruginosa [117], using a panel of 16 type O monovalent antisera (Bio-Rad, Belgium).
To confirm and explore the grouping of C-terminal POMs that resulted from pair-wise mapping data and to gain further insight on their binding specificities and cross-species reactivity, a panel of wild type and point-mutated recombinant PrP proteins were tested by western blot.
23 Additive/synergistic activity has been reported following the coadministration of imatinib and nilotinib in a panel of wild type and imatinib-resistant Bcr-Abl-expressing cell lines.
For this purpose, we evaluated a combination of Mini-and Microsatellite loci in a panel of 84 type C Map isolates, each recovered from a different Italian cattle herd.
In order to assess assay specificity, DNA from a panel of 37 type or in-house reference strains of different bacterial origin was submitted to the above described PCR procedure and subsequent hybridisation (Table 2).
Here we performed a focused 5C analysis of a 2.8 Mb chromosome 7 region surrounding CFTR in a panel of cell types.
To characterize the hypothalamic NS obtained and establish whether cells forming the NS exhibit multipotentiality, the expression of a panel of cell-type specific marker genes such as NSE (neuron specific enolase neuronal marker), GFAP (astrocyte marker) and Nestin (neuroepithelial/undifferentiated cell marker) was studied by RT-PCR.
Once activated, the T-lymphocytes excrete a panel of Th1-type proinflammatory cytokines, which are thought to explain many of the histopathological changes seen in psoriatic skin.
In the present study, we have used nutlin-3 as a novel approach to activate p53 and the intrinsic apoptotic pathway in a panel of wild-type p53-expressing human cancer cell lines.
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