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WUSCHEL-related homeobox 3A (OsWOX3A) is encoded by NARROW LEAF2 (Nand) aNAL3aL3, a pair of duplicated genes.
Deciphering whether a pair of duplicated genes has evolved divergent functions is often challenging.
Despite the advance in our understanding of the role of gene duplication in the evolution of new genes and gene families, deciphering whether a pair of duplicated genes has evolved divergent functions is often challenging.
The prevailing theory predicts gene loss or functional diversification as the main fate for one of two copies of a pair of duplicated genes [ 17].
In this study, we utilized a comparative evolutionary approach to this problem, focusing on differences in the high-dimensional properties of a protein, specifically the electric charge, encoded by a pair of duplicated genes.
We assayed the steady-state levels of fabp mRNA and heterogeneous nuclear RNA (hnRNA) transcripts for four sets of duplicated fabp genes, fabp1a/fabp1b.1/fabp1b.2, fabp7a/fabp7b, fabp10a/fabp10b and fabp11a/fabp11b in zebrafish fed different concentrations of clofibrate to determine if clofibrate induced transcriptional initiation of only one of a pair of duplicated fabp genes.
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Both subfamilies are typically single copy, but each was found as a pair of duplicate genes in teleosts, consistent with the teleost genome duplication event.
We inferred that a pair of duplicates would be WGD-derived co-orthologs if they were located on human-T.
We elaborated a model in which a pair of duplicates systematically exhibits cross-reaction.
For example, a pair of duplicates can undergo both partial subfunctionalization and neofunctionlization.
Thus, proteins of a pair of duplicate genes tend to be closer to each other than those of a pair of non-duplicate genes in the S. cerevisiae network.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com