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The phrase "a number of surprising differences" is correct and usable in written English.
It can be used when discussing multiple unexpected distinctions or variations between two or more subjects.
Example: "In the study, we found a number of surprising differences between the two groups' responses."
Alternatives: "several unexpected differences" or "various surprising distinctions".
Exact(2)
Their results, published in the journal Nature Methods, reveal a number of surprising differences between the functional architecture of the human and macaque brains.
The unpublished structure of a second recombinant form of human recombinant insulin, from Intergen, at the same resolution, deposited as structure 3W7Y in the Protein Data Base (in June 2013) shows a number of surprising differences when compared with the Insugen (I) structure reported here.
Similar(58)
We observed a number of surprising non-intuitive effects.
These experiments revealed a number of surprising results.
Ribosome profiling has already provided a number of surprising observations.
A number of surprising and highly diverse trends were found, which are summarized in Table 6.
However, a number of key differences emerged.
However, there are a number of differences.
"A number of teas are surprising in the Bkon," Barenholtz says.
The illegal part struck us -- and a number of readers -- as surprising.
There are a number of potential explanations for this surprising finding.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com