A number of substituted catechols were obtained using the recombinant biocatalysts.
As part of a discovery effort aimed at identifying novel norepinephrine reuptake inhibitors (NRIs), a number of substituted morpholines were designed and synthesized.
It is shown that the technique is applicable to unsubstituted benzene and a number of substituted benzenes by quantitatively reproducing experimental values of mean optical polarizability and optical anisotropy simultaneously.
Having established that the introduction of a benzoyl substituent at N 5) retained activity and affinity at the CB2R, and selectivity over the CB1R, a number of substituted analogues were next explored.
Pyranose dehydrogenase catalyzes the oxidation of free, nonphosphorylated sugars and the transfer of resulting electrons to a number of (substituted) quinones and complexed metal ions rather than to molecular oxygen.
If you don't have any, you can use a number of similar substitute, such a simple syrup; a couple of spoonfuls of sugar; a little corn syrup, or Sprite.
A number of 8-substituted-9-deazaxanthine derivatives (1,3-dialkyl-6-substituted-1H-pyrrolo[3,2-d]pyrimidine-2,4 3H,5H -diones) were prepared and tested for their antagonistic activity at the recombinant human adenosine receptors, in particular at the A2B and A2A receptor subtypes.
The electrooxidative behaviour of tetraphenylcyclopentadienone (tetracyclone) and a number of its substituted derivatives have been studied by cyclic voltammetry.
A number of alkyl substituted betamethasone 17α-carbamates were identified with excellent affinity for the glucocorticoid receptor (e.g., 7, GR IC50 5.1 nM) and indicated dissociated profiles in functional assays of transactivation (rat tyrosine aminotransferase, TAT, and rat glutamine synthetase, GS) and transrepression (human A549 cells, MMP-1 assay).
In addition, a number of compounds substituted at the primary amino group display improved activity relative to tranylcypromine 2 and are selective for the KDM1 family over related amine oxidases [67 69].
