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The phrase "a number of significant" is correct and usable in written English.
It can be used when referring to multiple important items, factors, or aspects in a discussion or analysis.
Example: "The study revealed a number of significant findings that could impact future research."
Alternatives: "several important" or "many notable".
Exact(59)
A number of significant achievements quickly followed.
But our findings do have a number of significant implications.
Over the years Radin wrote a number of significant works.
The program was faced with a number of significant challenges.
Herschel's mission yielded a number of significant findings.
Global conferences have served a number of significant functions.
In this area he made a number of significant contributions.
Tackling more numbers, there were a number of significant milestones reached at the weekend.
The uranium that makes conventional nuclear power possible has a number of significant disadvantages.
First, the Florida Supreme Court plainly rewrote the election laws in a number of significant respects.
Well, at least, in a number of significant respects, we know where we are.
More suggestions(25)
a number of significant proposals
as a book of significant
a number of significant difficulties
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a number of tangible
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a number of huge
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a number of tremendous
a number of remarkable
a proportion of significant
a number of salient
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com