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The phrase "a number of setbacks" is correct and usable in written English.
It can be used to describe multiple difficulties or challenges encountered in a situation or process.
Example: "Despite a number of setbacks during the project, the team managed to meet the deadline."
Alternatives: "several obstacles" or "multiple challenges".
Exact(47)
But the party suffered a number of setbacks.
However, there were a number of setbacks too.
But Mr. Picard suffered a number of setbacks.
As Brazil's football team prospered, Garcia Schlee endured a number of setbacks.
The Haitian economy has been reeling from a number of setbacks over many years.
Recently, there have been a number of setbacks in this regard.
Similar(12)
Massey has faced a number of recent setbacks and controversies.
Fantex has had a number of early setbacks.
The Chicago Teachers Union has absorbed a number of recent setbacks.
The coalition government had faced a number of recent setbacks.
The building also has a number of irregular setbacks that allow for dramatic terraces.
More suggestions(18)
a number of defeats
a number of breakdowns
a number of disasters
a number of impediments
a number of repercussions
a number of frustrations
a number of failures
a number of misfortunes
a number of vicissitudes
a number of difficulties
a series of setbacks
a number of obstacles
a lot of setbacks
a number of drawbacks
a number of shocks
a number of reversals
a number of complications
a number of hindrances
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com