The present studies identified a number of FGF-modulated miRNAs encoded by rat chromosome 6q32.
Biomarker studies also identified a number of bexarotene-modulated genes both in vivo and in vitro.
We also examined the regulation of a number of rexinoid-modulated genes including critical growth and cell cycle regulating genes using breast cell lines and mammary gland samples from mice treated with rexinoids.
In conclusion following an acute DSS treatment, Mutyh−/− mice display a lower number of modulated genes as compared to wt animals, when either up-regulated (4 versus 9 genes) or down-regulated genes (7 versus 13) are taken into consideration.
A high number of modulated genes are involved in glycosaminoglycan (GAG) and proteoglycan biosynthesis, diversification and sulfation.
It is of interest that a large number of modulated miRNAs were pointed out to interact with SRC (mmu-miR-197 and -230), CRK and CRKL (mmu-miR-203, -497, -218, -320, -214, -328), and various MAPKs (4 miRNAs for MAPK1, 3, 8 and 14; 7 miRNAs for MAPK9; 13 miRNAs for MAPK7; see Tables S5-S10 for details).
A high number of modulated transcripts of both genotypes were of unknown function.
Analysis of the biomarker changes induced by Chemo-placebo revealed a large number of modulated proteins, 119 markers at T1 and 132 at T2.
The results showed an increasing number of modulated genes with the absorbed dose, and a peak in the number of upregulated transcripts with the dose was seen at 10 Gy after 5 h.
In Ofanto the combination of drought and heat stress led to an increased number of modulated genes, exceeding the simple cumulative effects of the two single stresses, whereas in Cappelli the same treatment triggered a number of differentially expressed genes lower than those altered in response to heat stress alone.
