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In agreement with this finding, chemical upregulation of the HSR in cells and nonmammalian animal organisms reduced a number of dysfunctions caused by polyQ overexpression (see Fig. 2 for associated references).
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Exposure to ethanol during development induces severe brain damage resulting in a number of CNS dysfunctions including microencephaly and mental retardation in humans and in laboratory animals.
If emotions are repressed for a long time, this can lead to a number of mind/body dysfunctions, such as suppressed emotions, especially anger, sleeping disturbances, dizziness, fatigue, a feeling of obstruction in swallowing, indigestion and bowel dysfunctions [27].
Inflammation is an important contributor to the aetiology of a number of bladder dysfunctions.
Type 2 diabetes has been associated with a number of neutrophil dysfunctions.
Inflammation is an important contributor to the aetiology of a number of bladder dysfunctions including interstitial cystitis, painful bladder syndrome, and overactive bladder.
Disturbances in oxygen utilization are common in sepsis and a number of mitochondrial dysfunctions have been described in different tissues in septic animals as well as in septic patients.
A number of immune dysfunctions have been reported in sepsis, including apoptosis of T lymphocytes and B lymphocytes, altered cellular cytokine production, increased levels of the anti-inflammatory IL-10, impaired phagocytosis, monocyte deactivation with diminished major histocompatibility class II molecule expression, and altered response to microbial products [ 17- 22].
These transformations imply a number of serious hydraulic dysfunctions, underlined by the recent floods affecting the floodplains in Europe.
The loss of variability in the physiological systems in general, and in the cardiovascular system in particular, has an association with a number of diseases and dysfunctions.
Collectively our data illustrates that reduced levels of active MMP-2 (and absence of MMP-9) may contribute to a number of the phenotypic dysfunctions observed in DPN.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com