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The phrase "a number of different groups" is correct and usable in written English.
It can be used when referring to multiple distinct groups in a context where variety or diversity is emphasized.
Example: "The conference will feature presentations from a number of different groups, each sharing their unique perspectives on climate change."
Alternatives: "several distinct groups" or "various different groups".
Exact(31)
These early fish include a number of different groups.
We've had overtures from a number of different groups".
Of course, a number of different groups would love a cut of that action.
These early fish are collectively called "ostracoderms", and include a number of different groups.
By Dan Kaufman During Nels Cline's residency at the Stone, he performs in duets and with a number of different groups.
It has been raised with us by a number of different groups, including representatives of the Dalai Lama and the Chinese embassy".
Similar(29)
"One of a large number of different groups of people who have taken the Pi and [built something with it].
Specifically, the data sets ended up clustering into a small number of different groups, each with easily identifiable characteristics.
However, the production of sporopollenin is highly likely to be pre-adaptive as it is present in a number of different algal groups such as the charophyceans, which have been proposed as the sister group to the embryophytes.
There are a number of different opposition groups to Colonel Gaddafi in Libya who do seem relatively disparate.
Findings show that although the process involves a number of different professional groups and committees, the information flow among them is restricted.
More suggestions(15)
a number of various groups
a number of different population
a number of disparate groups
a lot of different groups
a number of small groups
a number of different levels
a number of different critiques
a number of nonprofit groups
a number of different types
a number of environmental groups
a plethora of different groups
a number of different organisations
a number of different reasons
a number of different options
a number of different models
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com