a novel rationale

USAGE SUMMARY

The phrase "a novel rationale" is correct and usable in written English.
It can be used when discussing a new or innovative reason or justification for a particular idea, action, or theory. Example: "The researchers presented a novel rationale for their approach, which challenged existing theories in the field."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

13 human-written examples

This study not only enhances our knowledge of the immunopathological mechanism of uveitis but also provides a novel rationale to target CXCR4 as an anti-inflammatory strategy to treat uveitis.

Experimental Eye Research

Using these data in a restrained ensemble docking protocol, we obtained a model for the ternary complex that reveals a novel rationale for the hierarchical assembly of the complex.

Journal of Molecular Biology

Envisaging a novel rationale for an effective therapy, the current review summarizes the main cellular and molecular mechanisms underlying cisplatin resistance and the impact of chemotherapy challenge in CSC selection and clinical outcome.

Drug Resistance Updates

The study revealed that frequencies of CD11bCD14CD33CXCR4 MDSC migration closely correlates with PGE2 and CXCL12 levels in patient ascites, suggesting a central role for PGE2 in MDSC accumulation regulated by the CXCL12/CXCR4 pathway and providing a novel rationale to target PGE2 signaling in ovarian cancer treatment (Obermajer et al., 2011).

Protein & Cell

Our mouse model provides a novel rationale with TME-targeted strategy for the development of cell-based cancer immunotherapy.

Cancer Science

This provides a novel rationale for assessing the potential of drugs targeting the proteasome for their anti-fibrotic properties.

Arthritis Research and Therapy

Human-verified similar examples from authoritative sources

Similar Expressions

46 human-written examples

Therefore, there may exist a novel molecular rationale for new platinum antitumor drugs development in the twenty-first century.

Critical Reviews in Oncology-Hematology

This provides a novel preclinical rationale for therapeutics aimed at interfering with the architectural organization of tumor-associated ECM.

BMC Cancer

Our results provide a novel biochemical rationale for combining MnSOD inhibition with oxidative stress-inducing therapeutic agents, which paradoxically also stimulate IL-6 and thereby counteract oxidative stress, for the development of an effective new therapeutic strategy for treating MM.

Biochemical Journal

These beneficial effects may derive from enhancement of EPC functions and homing process, which provide some novel rationale for the vascular protective properties of IFR therapy in diabetic patients with critical limb ischemia or further clinical implication in cell therapy.

Cardiovascular Diabetology

These beneficial effects may provide some novel rationale for the vascular protective properties of IFR therapy in diabetic patients with critical limb ischemia or clinical implication to treat dysfunctional EPCs before cell therapy.

Cardiovascular Diabetology

Expert writing Tips

Best practice

Use "a novel rationale" to introduce a new or innovative reason for a decision, action, or belief. This phrase works best when contrasting with established or conventional rationales. For example: "The company adopted a novel rationale for its marketing strategy, focusing on sustainability rather than immediate profit."

Common error

Avoid using "a novel rationale" when a simpler, more direct explanation is sufficient. Overusing the phrase can make your writing sound pretentious or unnecessarily complex. If the reason is straightforward, opt for phrases like "the reason is" or "the explanation is."

Linguistic Context

The phrase "a novel rationale" functions as a noun phrase, where 'novel' modifies 'rationale'. It serves to introduce a reason or justification that is new, original, and innovative. As per Ludwig AI, the phrase is grammatically correct and usable in written English.

Expression frequency: Uncommon

Frequent in

Science

75%

News & Media

20%

Formal & Business

5%

Less common in

Wiki

0%

Encyclopedias

0%

Reference

0%

Ludwig's WRAP-UP

In summary, "a novel rationale" is a grammatically sound phrase used to introduce a new and innovative justification. While not overly common, it appears most frequently in scientific and academic contexts, with some presence in news media. Ludwig AI confirms its usability, recommending it for introducing innovative reasons or justifications. When employing this phrase, ensure the 'novelty' aspect is genuine, avoiding overuse in simple explanations. Consider related phrases like "a new justification" or "an innovative justification" for subtle variations in meaning.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a new justification

Replaces "novel" with "new", indicating a recent or previously unknown reason.

an innovative justification

Substitutes "novel" with "innovative", emphasizing the creativity of the rationale.

a unique justification

Replaces "novel" with "unique", highlighting the distinctiveness of the rationale.

a fresh perspective

Offers a figurative shift, suggesting a new way of viewing a situation to provide a rationale.

a groundbreaking explanation

Emphasizes the potential impact and originality of the rationale.

an unprecedented reason

Highlights that the rationale has not been seen or used before.

a creative explanation

Focuses on the inventive nature of the reasoning.

an original argument

Indicates that the rationale is based on new and inventive thinking.

a transformative justification

Suggests the rationale leads to a significant change or improvement.

a pioneering rationale

Emphasizes the innovative and forward-thinking nature of the justification.

FAQs

How can I use "a novel rationale" in a sentence?

Use "a novel rationale" to introduce a new, innovative, or previously unconsidered justification for something. For example: "The study presents a novel rationale for the drug's effectiveness."

What's the difference between "a novel rationale" and "a new rationale"?

"A novel rationale" implies a fresh, innovative reason, while ""a new rationale"" simply indicates a recent or previously unknown reason. Novel emphasizes originality.

What can I say instead of "a novel rationale"?

You can use alternatives such as "a new justification", "an innovative justification", or "a unique justification depending on the context.

Is "a novel rationale" formal or informal?

"A novel rationale" is suitable for formal and academic writing. In more casual contexts, simpler phrases like "a new reason" might be more appropriate.