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The phrase "a noticeable difference however" is correct and usable in written English.
It can be used to indicate a contrast or exception after stating a noticeable difference between two or more things.
Example: "The results were similar in many aspects; a noticeable difference, however, was observed in the final outcomes."
Alternatives: "a significant difference nonetheless" or "a clear difference, on the other hand".
Exact(1)
A noticeable difference, however, was an increase in the number of shorter ORFs (20AA – 169AA) for the consensus data.
Similar(59)
One noticeable difference however was that those resident in more wealthy areas described the purchase of aids such as commodes and different types of incontinence pads in response to new problems while those living in areas of higher socio-economic deprivation described a reliance on access to National Health Service (NHS) provision of aids and incontinence pads.
The process of change is clunky and started way before Rana Plaza, however, a noticeable difference in the past 12 months (that the Rana Plaza disaster has made) is the mainstreaming of the debate, through media, social networks and campaigning efforts such as Fashion Revolution Day.
However, a noticeable difference was observed with respect to the transcript levels produced by the native ligA and the PligA-controlled gfp (Figure 1 versus 9).
However, a noticeable difference between rural and urban residents was that 67% of the rural oldest old rely on sons/daughters-in-laws for care, but this proportion was about 20% lower in urban areas.
It should be noted that follow-up headways did not vary appreciably by entry lane, but there was a noticeable difference between cars and heavy vehicles; however, the sample size for heavy vehicles resulted small, and did not lead itself to statistical testing.
However, there is a noticeable difference in power distribution between the PEP and the proposed design for L = N p = 16.
An individual might appear to function normally, however, there's a noticeable difference or a suspicion that something is wrong.
However, there was a noticeable difference in the expression of MMP-1 in the dermis, which exhibited both intracellular and extracellular staining.
However, there is a noticeable difference by children's enrollment status: 65% of the children enrolled in school and 73% of non-enrolled children have mothers in the oldest age group.
Like the ClearType system on Microsoft Reader, however, CoolType will make a noticeable difference primarily on monitors with liquid crystal displays.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com