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The phrase "a noteworthy weakness" is correct and usable in written English.
It can be used to highlight a significant flaw or shortcoming in a person, system, or argument.
Example: "In her analysis, she pointed out a noteworthy weakness in the proposed strategy that could hinder its success."
Alternatives: "a significant flaw" or "an important drawback."
Exact(1)
A noteworthy weakness of our study is the relatively small number of cases evaluated (including a particularly small number of cases with both LOH and RNA expression data to evaluate, due in part to the 500K chip mean heterozygosity of 27%), which limited our power to detect significant differences in loci between LOH and non-LOH groups.
Similar(55)
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And at the end of a noteworthy day came another noteworthy occurrence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com