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The phrase "a noteworthy setback for" is correct and usable in written English.
It can be used to describe a significant obstacle or challenge faced by someone or something, often in a context of progress or achievement.
Example: "The unexpected funding cuts were a noteworthy setback for the research team, delaying their project timeline."
Alternatives: "a significant obstacle for" or "a major hindrance to".
Exact(1)
The ruling represents a noteworthy setback for the IRS.
Similar(58)
Canada has a noteworthy reputation for high quality health care.
The boycott lasted a year and was a major setback for polio eradication.
So if it doesn't result in a victory it is a very negative thing and a setback for the club and one of several setbacks".
Well, folks, a big setback for NASA.
Or a major setback for feminism?
This is a minor setback for Leftwich.
It's a tough setback for him".
But it is a serious setback for judicial campaign reform.
This would be a severe setback for Internet users.
December's airport bombing was a big setback for him.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com