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The phrase "a noteworthy challenge" is correct and usable in written English.
It can be used to describe a challenge that is significant or deserving of attention, often in contexts such as discussions about projects, tasks, or obstacles.
Example: "Completing the project within the tight deadline proved to be a noteworthy challenge for the entire team."
Alternatives: "a significant challenge" or "an important challenge".
Exact(1)
The unpredictability and considerable variation in time to death may constitute a noteworthy challenge for accomplishing organ procurement after cardiac death.
Similar(56)
In a particularly noteworthy challenge, Mr. Bezard noted, Mastercard recently announced a partnership with Certapay, a Toronto technology company that could give Mastercard the technical means to create a competing system.
People living in rural and semi-rural areas account for a substantial proportion of the population in many sub-Saharan African countries, but conducting research in these settings has noteworthy challenges.
In conducting the trial, we encountered several noteworthy challenges and limitations: To accrue the 867 patients ultimately enrolled in the study, we attempted to reach more than 15,000 patients by telephone and screened over 6000.
Additionally, the World Bank instituted the "small island state exception" as a noteworthy response to the financing challenges of small island developing states.
Enzyme immobilization offers a noteworthy solution to industrial and environmental challenges faced by the modern world predominantly in the applications of enzymes in agro-waste management, textile effluents decolorization, and alternatives of health hazardous chemical based procedures.
However, a noteworthy new single molecule sequencing method currently in development is nanopore sequencing which may challenge PacBio's dominance in this area.
But a noteworthy destination?
He's a noteworthy person.
It was a noteworthy qualifier.
It's a noteworthy interview.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com