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Its principle is to drill a hole at or close to the crack tip to transform the crack into a notch, reducing in this way its stress concentration effect.
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Notch-1 stimulation in MDA-MB-231 cells increased survivin expression, whereas silencing Notch reduced survivin levels.
Moreover, administration of a Notch inhibitor reduces goblet cell metaplasia in an ovalbumin-induced asthma model (Kang et al., 2009).
Finally, it was found that the different curves of IDc versus test temperature (T) for different notches reduced down to a master curve if plotting IDc versus TBTm T, where TBTm was the TBT of PP itself for a given notch, indicating that TBTm T was a more universal parameter that determined the BDT of polymers.
Notches reduce significantly the lifetime of cyclically loaded components due to their stress concentration and early crack initiation.
In the FFEM, the large number of unknown variables in the singular region around a notch tip is reduced to a small set of generalised co-ordinates by performing a fractal transformation using global interpolation functions.
Mechanistically, Dishevelled binds and directly inhibits CSL transcription factors downstream of Notch receptors, reducing their activity.
For example, siRNA knockdown of the Notch receptor decreased Notch availability and reduced Notch activation by Dll1 ligands adhered to cell culture plate surfaces.
Consistent with this notion, the mRNA levels of the Notch receptors (Notch1 and Notch3) and Notch ligand (Jag1) as well as that of a Notch target (HeyL) were reduced by ~50% in primary myoblasts derived from mdx mice compared to those from WT mice (Fig. 3E).
We hypothesized that this implant would have in the short term: (1) clinical results and complication rates (other than scapular notching) that are comparable to implants with a similar design but without inverted materials; (2) a lack of wear-induced osteolysis, evidenced by a different radiographic appearance of the notching; (3) a reduced incidence rate of notching.
The repeatability of the fatigue initiating mechanism for corrosion damaged surfaces in this material indicates that it should be possible to develop a single modeling approach that reasonably captures the effects of corrosion notches in reducing fatigue life.
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