Within this are some notably severe figures, particularly a trenchant 81% cut to schools infrastructure, the continued result of Gove's decision to scrap Labour's Building Schools for Future (BSF) programme, while curbing Sure Start plays its part in a 17% reduction to the children, young people and families budget.
They cause a variety of diseases in humans, notably severe, protracted lung disease in patients with underlying lung disorders.
A combination regimen of cisplatin and gemcitabine was developed and compared with M-VAC, producing comparable efficacy results, and a reduction of side effects (most notably severe mucositis and infections, as well as alopecia) (Von Der Maase et al, 2000).
Notably, severe erosion areas in 1975, 1958 and 1982 are all quite extensive.
Not only was his treatment notably severe, but the Department of Justice also aggressively pursued Risen, essentially threatening the journalist with imprisonment for refusing to disclose his source.
The agency's report came as other signs of economic weakness were further revealed, notably severe drops in port calls and automotive production.
The decadal scale droughts of the 1920s 1930s and 1980s 1990s, particularly in the Sacramento and San Joaquin river basins, remain notably severe in the centuries-to-millennium context (California Department of Water Resources 2015).
Most notably, severe bradycardia, tachycardia, and hypoxia were all strongly associated with under-triage of high-acuity patients to moderate-acuity ESI triage levels (OR 2.55, 95% CI 1.54 4.02; OR 2.17, 95% CI 1.61 2.88; and OR 2.18, 95% CI 1.48 3.12, respectively).
However, notably, severe anaemia (haemoglobin <500 g/l) at admission was not associated with mortality.
Notably, severe hepatotoxicity, as seen with ansamycin-based HSP90 inhibitors in GIST, did not occur.
