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A notable downside to this strategy is that the extent of induction peaks and then decreases over time at higher cell densities (SI Figure S5), potentially complicating the tuning of expression levels.
It lacks 4G LTE — a notable downside to the phone in some markets.
Despite the listed advantages, the algorithm has a notable downside.
Indeed, this seems to be the notable downside of the policies of such neo-conservative pluggers as George W Bush, Paul Wolfowitz, Dick Cheney, Donald Rumsfeld.
The CDC endorses the vaccines-directed at influenza, pneumonia and shingles, each of which represents a greater threat to older people's than to younger adults' health-as clearly beneficial and without any notable downside.
Rochford: The most notable downside I've seen so far in working independently is that it takes much more effort and awareness to create a sense of community.
In theory this means Windows 10 computers are always up-to-date which gives hackers a much harder time, even if there are also some notable downsides.
On the downside, "unfortunately, holding back both Ciena's stock, in our opinion, and our rating, Ciena has shown a notable lack of discipline in managing its operating expenses," the research analyst said.
A potential downside of this approach is the loss of the statistical power of longer sequences.
On the other hand, a significant downside of the TKIs is a lack of specificity.
A potential downside of M&S is that it involves assumptions that cannot always be validated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com