Mug20, encoded by ORF SPBC36B7.06c, is a small 19.2 kD protein without any notable domain organization and homologs in other organisms.
Notable domain architectures and conserved gene neighbourhoods are shown to the right of tree.
The targeting of Erh1 and its associated factors requires Mmi114, which contains two notable domains, including a carboxy-terminal YTH domain implicated in binding to DSR-containing RNAs18,29,30,31,32,33 and a conserved amino-terminal domain that is largely unstructured30(this study).
Herein a reader might find a collection of the actual saved PSI-BLAST searches for all the notable domains described herein.
A notable decrease in Hck SH2 domain accessibility was observed in the presence of inhibitors 2 or 3.
The twisted β-sheet motif of domain I possesses a notable difference in its tertiary structure when compared with the PV, HAV, and HRV 3C proteases which, in contrast, display a complete β-barrel in this domain.
A notable feature of the C-terminal domain is that although it shows a lower degree of overall sequence conservation than the other regions, each of the major MIKC subfamilies possesses short, highly conserved diagnostic motifs at their C-terminal end (reviewed [ 21, 22]).
The large imprinted Kcnq1/KCNQ1 domain on mChr7/hChr11 is a notable exception to this.
Given the nearly complete conservation between predicted CckA proteins, the wAlb CckA protein lacking a C-terminal REC domain stands out as a notable exception.
On the other hand, there was a notable minority of participants suggesting that additional domains should be added to the questionnaire.
