The phrase "a notable difference is that" is correct and usable in written English.
You can use it to introduce a comparison or contrast between two or more subjects, highlighting a specific distinction.
Example: "When comparing the two studies, a notable difference is that one focused on urban populations while the other examined rural areas."
Alternatives: "a significant distinction is that" or "a key difference is that".
According to the figures, a notable difference is that the pitches of Kuijken's performance are one semitone lower than those of the other violinists' since the instruments are usually used in historically informed performances (HIP), and musicians usually follow the tradition of the period during which the music is composed.
In this story, a notable difference is that Caradoc's challenger is his father in disguise, come to test his honour.
A notable difference is that anaplerotic carbon sources such as malate, that act to replenish TCA cycle intermediate (TCAi) carbon loss due to cataplerosis (i.e., loss of TCAi carbon via export of α-ketoglutarate or its conversion to glutamate) are invariably included in isolated mitochondrial preparations to maintain function.
A notable difference is that 6.0% of all pancreatic cancer cases were diagnosed with DM II compared to 3.3% in the subcohort.
A notable difference is that in three mutants with stamen defects (ISS1, ISS2, and ISS5; Figure 5), no Y-chromosome deletions were detected using any of the Y-linked markers, whereas at least one marker was deleted in previously reported strains with flower mutations (summarized in Bergero et al. 2008).
A notable difference was that only 25% of the clinical material was seen at the hospital interface.
A notable difference was that the total soluble protein from tobacco leaves, in comparison to that from seeds, appeared to show some inhibitory effect on the growth of NFS-60 cells, as the cells treated with leaf extracts, with or without hG-CSF, yielded lower proliferation activity than the seed extracts and the control group.
A more notable difference is that in our simulations the shell is naturally formed from the supernova explosion mechanism, as opposed to the introduction of the supernova ejecta by an analytic description.
Another notable difference is that when B logically entails A, adding a premise C cannot undermine the entailment i.e., (C·B) must entail A as well.
One notable difference is that Scott is a history and political science buff and writes a weekly political column for the school newspaper; Jason, whose passion is environmentalism, is working to bring solar power to their school and district.
