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This may occur in part through a neutralizing effect on LDLR activity [ 30].
We next measured whether HPep1 and HPep6 had a neutralizing effect on LPS-induced TNF-α production in human PBMCs.
Such an effect can be explained either by a neutralizing effect on toxic α-helical Aβ or, alternatively, by these inhibitors blocking earlier stages in the aggregation process that can lead to the formation of the actual toxic species.
Despite the obvious lack of specificity for PsA, PGRN Abs are of particular interest because they had a neutralizing effect on PGRN plasma levels detected by ELISA and Western blot analysis [ 8].
Recently, we discovered progranulin autoantibodies (PGRN Abs) in a protein array-based screening of plasma from various primary vasculitides and found evidence that these PGRN Abs have a neutralizing effect on PGRN plasma levels [ 8].
These authors, as the result of their work, concluded that when sulfanilamide is implanted in a wound, the drug exerts a neutralizing effect on the toxins present, thus minimizing the amount of tissue breakdown, and that the drug converts bacteria into a static or non-pathogenic phase in which they do not invade the surrounding tissues and do not multiply.
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As shown in Figure 6 (A C), ActD had a clear neutralizing effect on RBV in most cell lines, while it had a somewhat mild effect on viral replication when used alone in most cell lines with the strongest negative effect observed in HEp2 cells for SeV and HeLa cells for VSV.
It had also a clear neutralizing effect on RBV in BHK21 and A549 cells, already highly resistant to RBV (Fig. 5).
In disagreement with previous work [11], PrioV3 antibody did alter PrPC expression, independent of the dose or treatment length (Figure 3 and data not shown), indicating that the antibody has a direct neutralizing effect on PrPC as well as PrPSc.
The Ca-amendment increased the soil pH and the dehydrogenase, β-glucosidase and acid phosphomonoesterase activity, but decreased microbial biomass carbon (MBC), probably as a result of the neutralizing effect on soil pH.
Guanosine had a clear (almost 100%) neutralizing effect on RBV in BHK21, A549 and Vero cells, which are already highly resistant to RBV.
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