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To illustrate the potential and challenges of the simultaneous analysis of a network of trials, using as a case study the investigation of the relative effectiveness of four topical fluoride treatments and two control interventions (placebo and no treatment) in preventing dental caries in children.
We simulated a network of trials as J meta-analyses of n j = n trials each.
A network of trials was randomly generated, using assumed input parameters (Table 1).
Suppose that several treatments (A, B, C, and so on) are compared in a network of trials.
We test whether there is an excess of trials with statistically significant results across a network of trials.
In a network of trials, conventional tests for asymmetry could be applied to each meta-analysis constituting the network.
Similar(48)
A general validation of DéciBlé is carried out using observed data from a network of field trials.
To enable multicriteria benefit risk (BR) assessment of any number of alternative treatments using all available evidence from a network of clinical trials.
We present a meta-analytic method that combines information on treatment effects from different instruments from a network of randomized trials to estimate instrument relative responsiveness.
11, 12 However, despite the sophistication and desirability of a network of compared trials, 13 the MTC approach is hampered by several important concerns.
Further quality was assessed according the Cochrane Collaboration's tool and data-extracted included papers and built a network of the trials.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com