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They allow unambiguous uncoupling of Met requirements for axonal growth from muscle development, and they also allow distinguishing of a nerve pattern defect from the consequences of an altered MN specification process (unlike for brachial Pea3 MN pools).
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Sarcopterygians, the sister group of actinopterygians, also exhibited an occipital-spinal pectoral nerve pattern.
The corneal confocal microscopy showed the presence of activated keratocytes, while the nerve pattern was normal.
To circumvent these caveats and examine signalling modalities of HGF/Met in a system where they exert direct control of axonal growth and guidance, we chose to investigate the motor nerve pattern in the dorsal hindlimb.
However, in the presence of equivalent amounts of muscle mass, such branches are unequivocally detected in met 2P/2P but not in met 2S/2S embryos, where the nerve pattern is indistinguishable from that seen in met d/d mutants.
While examining the nerve pattern, we found that the peroneal nerve of met 2P/2P embryos had a shape similar to that of control embryos, with an average α of approximately 135°, and its side branches in contact with EDL and TA were present in most cases (with an average number of eight side branches per nerve compared to nine per nerve in controls; Figure 3F).
However, a number of abnormalities in peripheral nerve patterns observed in met or hgf loss-of-function mutants [ 12, 17, 18], result from secondary effects of the absence of muscles, from the subsequent depletion of muscle-derived guidance signals and from early changes in MN specification [ 16].
Herrera-Rincon C, Pai VP, Moran KM, Lemire JM, Levin M. The brain is required for normal muscle and nerve patterning during early Xenopus development.
The pattern of the autonomic innervation of the trabecular muscle of the Lepisosteus respiratory bladder is basically similar to that of the tetrapod lung with overlapping of both muscle architecture and control nerve patterns.
The patterns generated by these thoughts, along with nerve patterns associated with facial movement, are then coupled with various commands within the BMI software in order to control the computer.
For successful regeneration to occur, proper nerve patterning is essential, so we examined whether Arch expression correlated with the position of neurons.
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