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The term "halogen bond" refers to the non-covalent interactions of halogen atoms X in one molecule with a negative site on another.
Halogen bond interaction, a noncovalent interaction between a halogen atom X in one molecule and a negative site in another, plays a vital role in fields as diverse as molecular biology, drug design and material science.
Each AWUAAA hexamer in these sequences was considered as a negative site.
The coordinates for the 11632 p63 bound locations and 30,000 negative genomic sites (any genomic site not within 5 kb of a p63 bound location was termed as a negative site) that had strong p63 canonical motif were obtained.
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In recent years, a "negative sites" strategy (no clinical effect at stimulation) is used in glioma surgery [18].
An alternative process by which dual regulation works is by the interplay between TF concentration and binding site strength: imagine two TFBSs for the same TF, a weak negative site inside a promoter and a strong positive site next to it.
In a recent study [ 9], biopsies of the AAA wall were obtained from regions with no 18F-FDG uptake and from regions positive for 18F-FDG uptake, both at the site positive for uptake and at a distant negative site of the AAA wall.
Ser is a positive regulatory site of eNOS, and Thr is a negative regulatory site of eNOS in that phosphorylation leads to increase or decreased enzymatic activity [ 10].
Phosphorylation at Ser, a positive regulatory site of eNOS associated with increased enzymatic activity [ 10], tended to be decreased, and phosphorylation at Thr, a negative regulatory site of eNOS associated with decreased enzymatic activity [ 10], tended to be increased in KKAy mice compared to control mice (C57BL/6 J).
Two PCR positive ticks (2.9%) had a negative attachment site.
In contrast, Thr is a negative regulatory site of eNOS in that phosphorylation leads to decreased enzymatic activity [ 10].
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