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This resulted in a negative ΔAPD90 value of −3.8 ± 1.6 ms in Scn5a+/Δ hearts.
A negative 2LnBF indicates evidence in favour of H0.
In group 2 (VEGF-A negative), only 2/11 of the cases (18%) had a malignant outcome.
Additionally, STAT3 induces expression of suppressor of cytokine signaling-3 (SOCS-3), a negative regulator of STAT3 activation [65], [78].
Specifically, transfection of STAT1C into EC1 and EC109 substantially upregulated p21Waf1, a negative regulator of G1 cell-cycle progression [ 14].
It has been suggested that CBF2 is a negative regulator of CBF1 and CBF3 [ 24, 25].
CBF2/DREB1C is a negative regulator of CBF1/DREB1B and CBF3/DREB1A expression, and cbf2 mutant showed enhanced tolerance to abiotic stresses [38].
Keap1 is a negative regulator of Nrf2[ 35] 35].
While Eform of 3V2BN has a negative value of −75.2 eV, 3V2NB has a positive value of 98.1 eV.
MDM4 is regarded a negative regulator of p53 and cooperates with MDM2 to antagonize p53 [ 8- 10].
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