The phrase "a negative role on" is not correct in standard written English.
The correct expression would typically be "a negative role in" or "a negative impact on."
Example: "The new policy has played a negative role in employee morale."
Alternatives: "a detrimental effect on" or "a harmful influence on."
On the other hand, cyclin D1 appears to have a negative role on adipogenesis as Fu et al reported that this cyclin negatively regulates PPARγ-mediated adipocyte differentiation through recruitment of HDACs to the promoter region of PPARγ target genes (Fu et al, 2005).
It could be deduced that CO2 desorption is rate limiting step, and the decreasing of pH played a negative role on the RCOO- active intermediate.
So, the presence of a Mo bond coat as a barrier between the coating and the substrate has a negative role on the adhesion.
Moreover, it was found that surface fluorination of high-energy {001} crystal facets played a negative role on the gas sensing activity.
The direct oxidation of gaseous NO to NO2 is proposed as the main pathway for NO2 formation and the decomposition of surface nitrates at elevated temperatures plays a negative role on NO oxidation.
Modelled as porous media, the filter screens play a negative role on particle fluidization velocities; without screens, particles are fluidized faster because of the higher fluid velocities in the jet center region.
The research conducted on GPs in the UK supports a negative role of on-call work related to mental health.
In a recent study, wtIGFBP5 and mutIGFBP5 were transfected to MDA-MB-435 breast cancer cells and this study revealed a negative role of IGFBP5 on cell motility [23].
Another study demonstrated that overexpression of PPARγ suppressed glucose-stimulated insulin secretion from MIN6 cells, and pioglitazone augmented this inhibitory effect, suggesting a negative role of PPARγ on pancreatic β-cell function (25).
Indeed, a negative role of the cytoskeleton on either NF-κB [47], [48] or Ca2+ signaling [49] has been evoked.
These studies strongly suggest a negative role of muscle HDAC4 upregulation on the reinnervation process.
