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The two others are more sensitive to cholesterol, which inhibits hmgcr gene expression through a negative feed back loop.
Thus, activated Notch may promote lineage entry by activating LSTFs and expansion of lineage specific stem and progenitor cells by a negative feed back loop involving Hes/Hey transcriptional repressors.
Interestingly, a negative feed back loop, limiting HIFα activity in chronic hypoxia or upon re-oxygenation has been reported: PHD2 and PHD3 mRNAs are induced by low oxygen in a HIF-dependent manner to shut-down HIF activity; PHD1 transcription is oxygen-independent [8], [13].
Prall and colleagues proposed a model to explain how the embryo regulates the switch from FHF and SHF differentiation involving a negative feed back loop comprised of Nkx2.5, Bmp2 and SMAD-1.
The decrease in the expression of FAK, p130Cas, integrin α5 and particularly paxillin was more evident in the presence of fibronectin, indicating that an excess of C3G downregulates the outside-in signaling by a negative feed back mechanism.
Iκ Bα and Iκ Bz as inhibitory genes are activated by NF-κB in a negative feed back loop, which provides an effective mechanism for controlling the NF-κB activity [ 83, 84].
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We show differences of the synchronization basins of two Matsumoto-Chua's circuit (operating in either the Rössler-type attractor regime or the Double-Scroll-type attractor regime), coupled unidirectionally or bidirectionally through a negative feed-back controller.
Thus, molecular architecture of the endocannabinoid signaling machinery supports retrograde regulation of synaptic activity, and its similar blueprint in rodents and humans further indicates that 2-AG's physiological role as a negative feed-back signal is an evolutionarily conserved feature of excitatory synapses.
AVP stimulates a release of natriuretic peptides which subsequently reduce AVP secretion through a negative feed-back loop [14].
Merlin affects Rac trafficking to the plasma membrane and is a direct inhibitor of Pak1, suggesting a negative feed-forward loop between Rac/Pak and Merlin [16].
Signalling through STAT3 is only transient and is in part down-regulated by SOCS 3 (a target of STAT3) in a negative feed-back loop, hypothesized to protect cells from prolonged cytokine signaling [26].
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