Your English writing platform
Discover LudwigExact(3)
It could be that the degree of knockdown of MELK in the luminal cell lines did not go below a necessary threshold to cause a proliferation effect.
One possibility is that even though the percent up-regulation was substantial in resistant ALL samples, the initial basal expression levels may have been low, such that a necessary threshold level of GR was not achieved after steroid-mediated up-regulation.
As we consistently observe a much lower STAT3 activation by IL-27 in hepatocytes and hepatic stellate cells compared to IL-6 one can also speculate that the STAT3 activation after IL-27 stimulation does not reach a necessary threshold for efficient induction of STAT3-dependend genes such as SOCS3.
Similar(56)
A mean acceptability rating of 4 or greater in ≥75% participants was deemed a minimum necessary threshold.
But the choice of 60 days as the necessary threshold was a fairly arbitrary one, according to Dennis J. D'Amico, senior research scientist of the Vermont Institute for Artisan Cheese of the University of Vermont.
Therefore, for a chosen analytic strategy, the necessary threshold is likely to depend on the analysis plan, as well as on the design parameters such as ethnicity, sample size, or sequencing depth (because increased depth could identify more rare variants).
A petition urging the Obama Administration to prevent a controversial cybersecurity bill from becoming law has reached 100,000 signatures -- the necessary threshold to elicit a response from the White House.
Rice, a slugger for the Boston Red Sox, surpassed the necessary threshold by seven votes.
In these circumstances a jury will be unable to assess whether the reason for their loss of control has met the necessary threshold to be regarded as "a qualifying trigger".
So quite how R&D of a decision-support app also constitutes 'direct patient care' — the necessary threshold required for sharing data without explicit patient consent, in this instance — remains unclear.
Mr. Eisenstadt played with a keen ear for it, creating a breadth of sound with his drums and cymbals, but at the lowest necessary threshold of volume.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com