The phrase "a necessary interaction with" is correct and usable in written English.
It can be used when discussing the importance of engaging or communicating with someone or something in a specific context.
Example: "In order to achieve our goals, a necessary interaction with the stakeholders is essential."
Alternatives: "an essential engagement with" or "a vital communication with".
The necessary interaction with these forces will affect the survival and reproduction of the members of these societies.
This was not the case in the in vitro activated CD68+ cells and clearly confirms the necessary interaction with the cells environment described before [22].
Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks.
Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways.
Finally, we selected 10 compounds on the basis of the necessary interactions with the key residues to be experimentally validated in a bioassay.
We attempted to define a region of Tom1L1 necessary for interaction with clathrin as assessed by GST-pull down experiments using various fusion proteins of Tom1L1 (depicted schematically in Figure 7A) to retrieve clathrin heavy chain (CHC) from A431 cell cytosol.
Previous docking simulations indicated that the carboxy group is necessary for interaction with an arginine conserved in the ASKs (arginine R124 in BIN2) [ 54].
However, the E3 ligase activity of CHIP is not necessary for interaction with p42, demonstrating that a deletion mutant of Ubox or the H260Q mutant form with no E3 ligase activity of CHIP is still able to associate with p42 (Supplementary Figures 4a and b), reflecting that p42 may not be an E3 ligase substrate of CHIP.
A substantially rigid inhibitor with potent functional activity at the transporter (IC50 = 8 nM) was used to develop a model for the distance and orientation of key features necessary for interaction with the norepinephrine transporter (NET).
Taken together, our results indicate that residues 548 567 of the carboxyl terminus of M3R form an α-helix and suggest that its structural integrity is necessary for interaction with Gβ5-RGS7.
