Sentence examples for a narrow dose from inspiring English sources
In mouse models of Streptococcus pneumoniae [32] and Cryptococcus neoformans [33], antibody-mediated protection was also observed within a narrow dose range.
Further, sb-paclitaxel displays more-than-dose-proportional increases in systemic drug exposure over a narrow dose range [ 11– 11].
In vitro the differentiating effect of decitabine in cultured fibroblasts has a narrow dose window with a loss of action at high doses possibly caused by cytotoxicity as a result of its incorporation into DNA (Taylor and Jones, 1979).
The PK properties of KAE609 (i.e., long half-life) and the almost complete reduction in parasitemia reached in a narrow dose range do not allow us at this stage to clearly distinguish between concentration- and time-dependent killing for KAE609 in the investigated model.
Vinclozolin was active in a narrower dose range, with correspondingly steeper dose response curves, and the characteristics of prochloraz and DEHP fell between these extremes.
The current paradigm in regulatory toxicology of only testing a few very high doses of chemicals within a relatively narrow dose range (with the highest dose being the maximum tolerated dose) thus does not serve to predict the hazards posed by low-level exposure to numerous EDCs found in most people in biomonitoring studies conducted in the United States and elsewhere (Calafat et al. 2008).
The TDI was derived from LOAELs (lowest observed adverse effect levels) for a variety of adverse responses in experimental animals that occur in a relatively narrow dose range (WHO 1998).
Spleen volume changes may be dose sensitive within a relatively narrow dose range.
There is probably a narrow effective dose, and benefit may be limited to at-risk tissue.
However, pretreatment with oral doses of 5, 25, and 75 mg/kg did not improve mouse 30-day survival after irradiation (data not shown), suggesting a narrow effective dose range via oral route in irradiated CD2F1 mouse.
The number of the 800 or so workers at the Fukushima plant likely to receive radiation in that narrow dose range "would be pretty limited," Chao says.
