The phrase "a mutagenicity" is not correct in written English.
The term "mutagenicity" is an uncountable noun and should not be preceded by the article "a."
Example: "The study focused on the mutagenicity of various chemical compounds."
Alternatives: "mutagenic potential" or "mutagenic properties."
A mutagenicity dataset of 5,439 compounds was used in this proof-of-concept study.
Finally, to complete this comparison, a second external validation was performed using a mutagenicity dataset provided by the Center for Food Safety and Applied Nutrition (CFSAN) [30].
The algorithm is currently optimised for endpoints such as a mutagenicity where the activity is heavily based on the presence of reactive groups and inactivity can be defined as the absence of mutagenic structural features.
To achieve a tool more suitable for regulatory purposes, a mutagenicity classifier has been arranged integrating two different techniques: a machine learning algorithm from the Support Vector Machines (SVM) collection, to build an early model with the best statistical accuracy, then an ad hoc expert system based on known structural alerts (SAs), tailored to refine its predictions.
A curation effort was undertaken to improve the quality of the structural data and briefly assess the potential reliability of the experimental results of a mutagenicity benchmark dataset (Hansen) that was constructed by combining data from multiple sources [31]; not all of these sources provide the data in a readily available format.
V79 Chinese hamster lung cells were used as a mutagenicity test system [ 15].
We also noticed that methanolic, aqueous and TOF-enriched extracts were more efficient in reducing B(a)P mutagenicity than 2-AA mutagenicity.
Because an exposure of mammalian cells to KBrO3 generates oxidative DNA modifications, in particular 8-oxoG [ 49], we used KBrO3 in the HPRT test and observed a trend towards a reduced mutagenicity in states of frataxin overexpression (P=0.06).
The studies performed included a bacterial mutagenicity screen (Ames assay), a mammalian cell cytotoxicity assay (neutral red uptake), determination of smoke chemical constituents, and a 90-day nose-only smoke inhalation study in rats.
For more than a decade, mutagenicity tests have had a clearly defined role in the identification of potential human mutagens and an ancillary role in the identification of potential human carcinogens.
The efficiency of ENU is both strain and dosage-dependent, which is reflected by very large differences in mutation frequency in different mouse [ 7] and rat [ 5, 6] inbred strains and by a higher mutagenicity after three weekly administrations of low doses of the mutagen as compared to a single high-dose injection [ 7].
