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The interactions between the response to treatment (pNR vs pCR + pPR) and the variables statistically significant at univariate analysis were tested in the entire cohort and in the Luminal B/HER2− cohort in a multivariable binary regression model.
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In case of significant differences in baseline characteristics, which may have happen by chance as we only stratify randomization by sex and center, the primary outcome will additionally be tested using a multivariable binary logistic regression model to adjust for the following potential confounders: age, acute complicated pyelonephritis, underlying co-morbidity and the use of stepdown treatment.
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