Gene families (clusters) were retrieved by clustering a multitude of sequences of Archaeplastida proteins (Additional file 5: Table A4) using OrthoMCL [ 79].
Note, however, that apart from true miRNAs and the above-mentioned sequence variants, the dataset contains a multitude of sequences not related to miRNAs, such as other non-coding RNAs and mRNA degradation products.
The pyrosequencing approach was therefore expected to provide a multitude of sequences within both families of which the great majority was not expected to have any function related to cyanogenesis in Z. filipendulae.
Meningococci are highly variable bacterial pathogens, as shown by a multitude of different sequence types identified by multilocus sequence typing (MLST) (1 ) and by antigen sequence typing of the outer membrane proteins such as PorA (2 ) and FetA (3 ).
However, promoter recognition is likely to be compromised by the fact that RNAP is capable of binding, and possibly initiating transcription, at a multitude of DNA sequences.
Because RBM44 carries an RNA recognition motif (RRM) and the RRM could potentially bind a multitude of RNA sequences and proteins (reviewed in reference [29]), we suspect that RBM44 may function as an RNA-binding protein required for intercellular bridge function.
Our results show that wt p53 binds a multitude of promoter sequences causing increases in histone H3 and H4 acetylation.
One P. carinii unigene contig (contig961) had very high similarities to fungal citrate synthases (CIT1), as well as a multitude of corresponding genomic sequences (Table 5).. Contigs 749 and 808 shared high similarities to ATP citrate lyase subunits 1 and 2 (E.C: 2.3.3.8).
A part of the explanation may lie in the sheer size of the search space where competition from a multitude of highly similar sequences may not allow reliable assignation at low taxonomic levels.
Although a multitude of whole-genome sequencing projects ranging from microbial (e.g. [ 13]) to vertebrate genomes [ 14] have been initiated in the last decade, no complete genome sequence is available for crustaceans, a species-rich taxa with additional high economical impact.
