Sentence examples for a multistep process of development from inspiring English sources

Most of the tumours are associated with a multistep process of development with changes in host gene expression (Feitelson et al, 2002).

Using genetically engineered mouse models, we show that hepatocyte-specific expression of unconventional prefoldin RPB5 interactor (URI) leads to a multistep process of HCC development, whereas its genetic reduction in hepatocytes protects against diethylnitrosamine (DEN -induced HCC.

Current understanding of tumorigenesis assumes that a multistep process of changes leads to the development of cancer.

Finding a virus is only the first in a multistep process of determining whether it is harmless or causes disease.

The mechanisms for bone adaptation involve a multistep process of cellular mechanotransduction.

In addition, renal tumorigenesis in VHL disease appears to be a multistep process, as development of VHL-deficient renal cysts precedes onset of renal cancers [ 4].

The extended replicative lifespan that results from the inactivation of tumor suppressor pathways is thought to represent a pre-malignant stage of the multistep process of cancer development.

One may speculate that the recurring combination of a limited set of imbalance hot-spots is concordant with the multistep process of cancer development [ 78], and that these regions point towards preferential oncogenetic targets.

Proteomic studies are widely used in the search for new tumour markers Carcinogenesis is a multistep process leading to the development of multiple cell clones and heterogeneity as a result of tumour cell genetic instability.

All these methods try to recapitulate, in different ways, the multistep process of neural development that occurs in the embryo, from neural induction to the terminal differentiation of neurons and glial cells.

Such "oligomiRs" may be involved in regulation of oligometastatic phenotype during multistep process of metastases development.