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To help this happen, Popper wanted an open society with free data to allow a multiplicity of testing scientific experiments.
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Julio Rodriguez-Lopez, Manuel PoMyriamarez, Myriam Liz, Juan J Gomez-Reino and Antonio Gonzalez The letter from Ikegawa and colleagues highlights some difficulties in defining what constitutes replication of previous genetic association in the context of studies with different patient selections, ethnicities, environmental and cultural influences and a multiplicity of tests.
The minimum false discovery rate (FDR) at which each null hypothesis could be rejected using the method of Benjamini and Hochberg (1995) is also provided as a conservative statistical adjustment for the multiplicity of testing multiple gene models.
Finally, while other guidelines advise to keep sub-group analyses to a minimum, because of the inherent problems associated with multiplicity of testing [ 3] we were more concerned with under-analysing data.
Multiplicity of testing with 47 biomarkers in an individual sample also has unique statistical challenges in the imputation of missing data and interpretation of analyses.
No adjustment was made for the multiplicity of testing.
Nominal P values are presented without adjustment for multiplicity of testing.
Additionally, because of the multiplicity of testing between pairs of regression lines, the chance of error increases so a more stringent significance level should be adopted.
The significant SNPs were analyzed for multiplicity of testing to avoid false positives using false discovery rate (FDR).
Statistical comparisons were considered significant at the 0.05 probability level; no adjustments were made for multiplicity of testing.
However, the LD between the SNPs suggests that the tests were not independent, and thus Bonferroni method may overcorrect the multiplicity of testing.
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