Colorectal cancer development is widely accepted to involve the multifaceted progression of a benign lesion (adenoma) to invasive adenocarcinoma (hereafter referred to as 'carcinoma') by acquisition of a migratory, and ultimately invasive phenotype (Muto et al, 1975).
In this study, it was found that hepatocyte expression of Snail has a multifaceted effect on the progression of liver fibrosis through regulation of growth factor expression and ECM synthesis, which impacts hepatocytes themselves and other cell types.
The tumour stroma contains CAFs (cancer-activated fibroblasts), similar to the transformed fibroblasts observed in wound healing and fibrosis [ 16], that play a multifaceted role in tumour progression.
β1-integrins are critical mediators of normal cell-ECM interactions and have been shown to play a multifaceted role in malignant progression [ 7].
However, the very recent data by Rolny et al (2008) suggest a reconsideration of this semaphorin as a multifaceted regulator of cancer progression: SEMA3B inhibited tumour growth in mice but simultaneously and unexpectedly triggered metastasis by activating the signalling kinase p38.
Luo, H., Tu, G., Liu, Z. & Liu, M. Cancer-associated fibroblasts: a multifaceted driver of breast cancer progression.
To the best of our knowledge, our present findings are the first report providing a new insight into a putative mechanism by which TSG101 bidirectionally participates in carcinogenesis and tumor progression as a multifaceted gene in different cell types.
ANXA1 expression is "tumor-specific" and might play a multifaceted role in cancer development and progression.
Our data confirmed that ANXA1 expression is different in different types of tumor and plays a multifaceted role in cancer development and progression.
All these results revealed a multifaceted pathway of Notch1 activation underlies tumour progression.
Taken together, tumor-specific cell cell contacts can provide a multifaceted survival advantage throughout the course of pathologic progression.
