Lubricin/proteoglycan-4 (PRG4) is a glycoprotein secreted from synovial fibroblasts and superficial zone chondrocytes that has a multifaceted function including boundary lubrication, resulting in lowering of friction between apposed cartilage surfaces [ 1– 9].
Mechanical properties of the cornea play a central role to its multifaceted function of serving as both a physical barrier and the primary refractive element in the eye.
The multifaceted function of NDE1 as a molecular scaffold might be fulfilled by post-translational modifications or through undergoing reversible transitions between monomeric and polymeric forms (Feng and Walsh, 2004; Soares et al., 2012), which facilitate its dynamic partition and reassembly into different molecular complexes.
Further, LF82Δhfq mutants were non-motile, impaired in cell invasion and highly sensitive to various chemical stress conditions, reinforcing the multifaceted function of Hfq in mediating bacterial adaptation.
Another alternative possibility regarding the multifaceted function of H2A.Z, at least within the vertebrate lineage, could be related to the presence in these organisms of two different H2A.Z variants, H2A.Z-1, and H2A.Z-2, (Fig. 2) that have been described at the beginning of this section [ 10, 11].
In summary, we have uncovered multifaceted functions of a small molecule previously widely regarded as a replication inhibitor.
Hence, a comprehensive understanding of the multifaceted functions of MAPK pathway components in tumor initiation and progression is essential for the improvement of cancer therapy.
Given the multifaceted functions of AA in plants, there is a need to advance our understanding of how plants regulate the biosynthesis and accumulation of AA.
These results unveil previously unrecognized multifaceted functions of β-catenin in the establishment and drug-resistant properties of MLL stem cells, highlighting it as a potential therapeutic target for an important subset of AMLs.
Such activities illustrate the flexibility and multifaceted functions of p53 variants.
