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On the contrary, the turn A containing N656, E657, L660 and L661, shows a much weaker interaction with the viral membrane (+5.4 kcal/mol).
On the contrary, a much weaker interaction leading to higher reducibility occurs for the silica-supported cobalt catalysts.
By co-immunoprecipitation, we observed a strong interaction between Nkd1myc and β-catenin, but a much weaker interaction between Nkd1G2A-myc and β-catenin (Fig. 5A).
The interaction of p53 with these cofactors is affected by the residue phosphorylated [41]; for example, Ser15 phosphorylation, or its aspartic substitution, favors binding to p300; while its substitution by alanine results in a much weaker interaction [42].
We could also observe a much weaker interaction for Fk4 (Fig. 5C) that agrees well with the effects these sites have on total Foxi1 mediated reporter gene activation (Fig. 5B).
A much weaker interaction between AD-Uls1 and BD-Slx8 also was observed.
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However, very little is known about the much weaker interaction between the GDP-bound Ras (RasGDP) and Ras effectors.
This difference should be based on much weaker interaction force of ether oxygens toward anions than that for cations.
With other nucleoside derivatives which have different numbers of phosphate units or different types of nucleobases, the much weaker interaction was detected.
Compared to CENP J, the full length CENP F showed much weaker interaction with the bait.
Chen et al. (2006) reported a significant synergistic effect between the highest level of arsenic exposure via drinking water (> 113 μg/L) and tobacco smoking for the risk of skin lesions among Bangladeshi men, but much weaker interaction effects among women.
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