Sentence examples for a much weaker affinity from inspiring English sources

The purines, adenine and guanine, have a strong affinity for the Ni-IDA matrix, while the pyrimidines, cytosine and thymine, have a much weaker affinity [6].

In addition these antibodies displayed a much weaker affinity for EBNA-1 and dsDNA making them less desirable to use in our initial attempt to identify epitopes in EBNA-1 that play a role in cross-reactivity to dsDNA.

Please provide an explanation for why AVR-PikE has a much weaker affinity with HMA than AVR-PikD.

A K-helix peptide containing two Leu-to-Ala mutations (Ac-WGIAA AKEKIAALKEKIAA AK-NH2) that shows a much weaker affinity for the E-helix sequence does not have this effect, indicating the interaction is occurring via formation of a coiled coil.

As XerC displays a much weaker affinity for dif and attP than XerD (Supplementary Figure S3), the primary effect of Endo III binding would be the loss of XerC-catalysis (as suggested in Figure 4) and its subsequent dissociation (as suggested in Figure 6).

We observed NMR spectra characteristic of tight binding at low micromolar concentrations (2 5 μM eIF4E) but much weaker affinity at more typical NMR concentrations (50 200 μM).

The NH2-terminal domain of IN (IN1 55) and the central core domain of IN (IN51 212) showed much weaker affinity compared to the C-terminal domain (IN201 288).

First, although human SP1 binds primarily to the GC box, it also recognizes the ancestral GA box consensus, although at much weaker affinity (Letovsky and Dynan 1989; Wierstra 2008).

The levels of Pax7 protein were also examined (Supplementary Figure S2), and we found further that Pax7 bound to this putative target site in vivo, albeit with much weaker affinity than that in the previously identified Id3 gene [ 34], implying that this site is a bona fide, but weak, Pax3/Pax7 target site mediating the Wnt3a effect.

This conclusion was reinforced by a study that used ITC (isothermal titration calorimetry) to examine the binding of the CR tandem construct CR56 (where CR xy is the LRP fragment containing domains CR x and CR y) from ligand binding cluster II of LRP to RAP domains D1, D2 and D3 that found moderately high affinity (0.2 μM) for D3, but much weaker affinity for D1 (3 μM) and D2 (19 μM) [ 14].

However, 6 has a much weaker binding affinity to XIAP and displays a selectivity of 613 times for cIAP1 over XIAP.