I do not understand why the results confirm that CD94L molecules are much more evolutionary conserved than Class I a molecules.
A mixed strategy is optimal unless one of the two fitness components (the growth potential or the number of neighbors) is much more evolutionary "expensive".
The other two genes in the region are much more evolutionary conserved and have gene trees that do not differentiate the two species.
This phenomenon indicates that SNPs impede the disease genes (AD, ID) to take part in alternative splicing by altering the splicing signals and their lower involvement with alternative splicing than IG genes may imposes much more evolutionary pressure on disease genes.
Nonetheless, the lack of specific resemblance to any juvenile annelid relatives indicates a much more complex evolutionary history than what can be explained by a one-step progenetic evolutionary process.
In fact the pattern of dinosaur feathers may have still been as we observe now (most without) but it would suggest a much more complex evolutionary pattern of body coverings in the group, and provide the potential at least for feathered or fuzzy sauropodomorphs or armoured dinosaurs.
The nuclear genes, on the other hand, present a much more convoluted evolutionary picture, with probably numerous ancient HGT events shaping the amino acid metabolism in trypanosomatids.
However, no such long and thin tail is observed experimentally for the primary tumor in Navin et al. It is still possible, if highly unlikely, that the metastatic cell is an extreme outlier, with no comparable cells left in the primary tumor, but then we would see a much more pronounced evolutionary difference between primary and metastatic aneuploid populations than what is observed.
However, biological considerations suggest that gene loss might be, in general, a (much) more likely evolutionary event than gene gain or at least than HGT; this is amply illustrated by the massive gene loss in parasites compared to their free-living relatives, e.g. Buchnera sp. vs. Escherichia coli, Mycoplasma genitalium vs. Bacillus subtilis or Rickettsia sp. vs. Mesorhizobium loti [ 43- 46].
On a much more philosophical level, however, evolutionary robotics may allow robots to develop complex social traits that are impossible to program, and may actually magnify a few newly discovered laws of nature.
