Sentence examples for a much lower affinity from inspiring English sources

Hydrous Al oxides and clay minerals have a much lower affinity for adsorption of As III) than do amorphous and crystalline hydrous Fe oxides.

However, pancreatic beta-cells also express the SERCA3 subtype (Varadi et al. 1996), which has a much lower affinity for Ca2+ (1100 nmol/L) than does SERCA2 (270 nmol/L) (Lytton et al. 1992).

In receptor binding assays, MJ15 displayed a high affinity for rat cannabinoid CB1 receptor (Ki = 27.2 pM, and IC50 = 118.9 pM), but a much lower affinity for rat cannabinoid CB2 receptor (only 46% inhibition at 10 μM).

The C2 domain of Protein-G from Streptococcus is a multi-specific protein domain; it possesses a high affinity (KD ~ 10 nM) for the Fc region of the IgG, but a much lower affinity (KD ~ low μM) for the constant domain of the antibody fragment (Fab), which limits some of its applications.

This probably reflects a much lower affinity of these drugs for a yet unidentified target in Leishmania compared with their high affinity for HIV peptidase [33].

This is consistent with the fact that zebrafish IGFBP-1b has a much lower affinity for IGF-1 and IGF-II.

These data suggest that using a fluorescent antagonist ligand under these conditions labels a species with much lower affinity for agonists than when a fluorescent agonist ligand is used.

1 5 We confirmed that bevacizumab inhibits VEGF-induced proliferation but is less efficient than ranibizumab; this was also observed in experiments with human REC and could be a consequence of its much lower affinity to VEGF. 12 18 Likewise, the ability of bevacizumab to re-establish an intact iBREC barrier that had been deranged by VEGF, was lower than that of ranibizumab.

In contrast, A-582941 was found to have much lower affinity for heteromeric α4β2 subtypes, as measured using [3H]cytisine binding to rat brain membranes (Ki>100,000 nM) [26].

RibU is strikingly different from the Corynebacterium glutamicum riboflavin transporter RibM, which was characterized as an energy-independent facilitator for riboflavin with much lower affinity (K m = 11 μM) [ 3].

Thrombin is a serine protease with high affinity for PAR1 and much lower affinity for PAR4 receptors [12], [15].