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The phrase "a much less significant" is correct and usable in written English.
It can be used when comparing the importance or impact of two or more things, indicating that one is notably lower in significance than the other.
Example: "The new policy has a much less significant effect on employee morale compared to the previous one."
Alternatives: "far less important" or "considerably less impactful".
Exact(17)
The other moral, less encouraging, is that popular culture is a much less significant marker of public attitudes than its close readers wish to imagine.
In 1999, based on perjury charges related to a much less significant matter, this same senator voted to remove the president of the United States from office.
And particularly in a freelance-centric, knowledge-skills environment, age is a much less significant factor than performance.
According to the three coefficient estimates, men's remarriage is also negatively influenced by their growing older but to a much less significant degree than women.
This represents a change from the findings of the Keay et al. study, in which prior PKP was a much less significant risk factor (65/733, 8.9 %).
Kim Sterelny (1996) has invoked the distinction between superorganisms and trait groups to argue that group selection is a much less significant force in directing evolution than proponents of group selection have thought.
Similar(43)
The Basal subtype mutations had the highest average ranking in the 95.2 percentile and the average Luminal B subtype mutations ranked lower in the 90.9 percentile, whereas the Luminal A mutation was much less significant with a ranking in the 78.3 percentile.
The effect of an upstream turbine wake on the wind turbine sited on a hilltop was found to be much less significant compared to a wind turbine on a flat surface.
Everyone is overlooking the other side of the story about the way the American government is treating its citizens who would give such a service (in fact much less significant) to Iran.
The results demonstrated a substantial shift with much less significant results.
That means a prediction having multiple binding sites in one sequence and none in the others is much less significant than a prediction having a balanced number of binding sites in each sequence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com