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Notably, INZ induced senescence in H460 or HCT116p53+/+, but not in HCT116p53−/−, cells, though to a much less degree than did Nutlin-3 (Fig 2F and G; Efeyan et al, 2007).
Of note, MAb 138 does detect the normal nuclear TDP-43 in QBI293 cells by ICC (Table 2), albeit to a much less degree or intensity than the other MAbs reported in our study (data not shown) and most published pan-TDP-43 antibodies.
However, the NPM-ALK-induced activation of mammalian target of rapamycin (mTOR), either transduced through the mitogen-induced extracellular kinase (MEK /extracellular signal-regulated kinase (ERK) signaling pathway, or to a much less degree, through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway has been shown to contribute to the tumorigenesis of ALCL [ 22, 23].
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The results indicated that the nanocomposites exhibited much less degree of ageing degradation, due to a strong UV shielding ability of the nano-TiO2.
The results demonstrated much less degree of ageing degradation for the nanocomposites, indicating an important role of the nano-TiO2 in improving the ageing-resistant properties of synthetic polymer composites.
The moving grid method enables us to obtain accurate numerical solutions with much less degree of freedoms.
Bones in great-horned owl pellets tend to be larger in size and show much less degree of corrosion and polishing compared to the scats and eagle pellet bones.
Even with much less degree of freedom than mRNAs, miRNA expression profiles reflect the developmental lineage and differentiation state of cells and successfully classified poorly differentiated tumors that could not have definitive diagnosis by histopathology, while the classification based upon the mRNA profiles was highly inaccurate [ 14].
A: Much less there.
(A similar awakening is had, to a much less tawdry degree, by the Nickelodeon star Ariana Grande on her recent single "The Way").
According to the three coefficient estimates, men's remarriage is also negatively influenced by their growing older but to a much less significant degree than women.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com