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In contrast, in the DNA melting experiments a much larger interaction surface for TFE is presented the entire RNAP and in this context the ZR deletion has no phenotype presumably because additional contacts compensate for the weakened interaction.
Integration of these observations results in the first structural view of the core Mediator-CTD interaction network, in which the extended CTD interacting extensively with Med17/Srb4 is proximal to the other four Srb subunits of the core Mediator, indicating a much larger interaction surface of the core Mediator for CTD binding.
There was no main effect of reversibility (F 1,23) = 2.34, P = 0.14), but there was a main effect of syntactic structure (F 2,46) = 5.23, P = 0.009) and a much larger interaction effect between reversibility and syntax (F 2,46) = 11.53, P = <0.0001).
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A third study by Fraser et al. [ 6] using a much larger protein protein interactions data set again found a correlation, and also showed that the conflicting results were due to differences in the interactions data sets rather than differences in the evolutionary rates.
Apparently, SAP PDZ domains are open to a much larger spectrum of interactions than that encoded in the genomic sequences.
Interest in the museum is "quite minimal relative to the importance of design right now," she said, and Mr. Moggridge should help give it "a much larger presence in and interaction with the design community and the public".
We achieve this while using a much larger candidate miRNA-mRNA interaction set than prior work.
Consistent with this, we found that the Drosophila HCS has a much larger overlap with genetic interactions than LCS and RPS (Fig. 4A).
For example, in the aforementioned work,[ 24] it was observed that water imbibed in Pd/Al2O3 catalyst trilobes exhibits a much larger T1/ T2 ratio (stronger surface interaction) than 2-butanone on the same surface; water is known to poison this palladium catalyst in the hydrogenation of 2-butanone by preferential adsorption on the active sites.
Note that for our first analysis of genetic interactions, we only chose synthetic lethal interactions; below, we also analyze a much larger data set of non-lethal genetic interactions.
Although many biologically significant interactions involve association of identical subunits, a much larger class of binding events involves interactions of dissimilar partners.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com