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Decreased levels of SQSTM1 have been reported to accompany LC3-II accumulation in a mouse models of contusive TBI (weight-drop model) (41).
To assess the feasibility of biomarker development in PDAC, we have also taken a mouse models approach using the p48-Cre/LSL-KrasG12D p48-Cre/LSL-KrasG12D p48-Cre/LSL-KrasG12D
Furthermore, it has been shown that its absence or ablation disrupts the establishment of endometriosis-like lesions in a mouse models (Styer et al., 2008).
In a mouse models of renal ischemia-reperfusion injury, Mishra and colleagues verified that the NGAL protein is expressed predominantly in the proliferating cell nuclear antigen-positive proximal tubule cells within 3 hours of ischemia [ 5].
In contrast to a recent study showing accumulation of hyperphosphorylated tau in both human cases and a mouse models of blast associated brain injury [ 13] we did not detect any accumulation of hyperphosphorylated tau in blast-exposed animals by immunostaining with the antibody CP-13, which recognizes phosphorylated tau at Ser202.
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To rule out SP-A-mediated opsonization contributed to the differential clearance of flgE mutant in SP-A mouse models, we compared the phagocytosis of flgE to PA01 bacteria in SP-A+/+ and SP-A−/− mice after intranasal inoculation in vivo, and in the presence and absence of SP-A, in vitro.
"Blocking tumor necrosis factor in a mouse model improves asthma," Dr. Remick said.
"We have shown proof of concept in a mouse model, and we are moving to the next stage".
"Given that features of Rett can be reversed in a mouse model," Dr. Zoghbi said, "one would predict that postnatal disorders like autism and schizophrenia might be reversible".
Navarro tried it in a mouse model of asthma.
A mouse model of S. aureus mastitis is available.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com