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These tumor-associated macrophages are known to support cancer progression rather than mounting anti-cancer responses.
Although generally correlated with later stages in disease progression, there is mounting evidence suggesting the metastatic process may initiate earlier in breast cancer development.
OBJECTIVE: A major determinant of the progression from insulin resistance to the development of overt type 2 diabetes is a failure to mount an appropriate compensatory β-cell hyperplastic response to maintain normoglycemia.
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However, C57BL/6 mice do not spontaneously mount an efficient tumor progression-limiting immune response to either tumor antigen during subcutaneous tumor growth.
While AD is usually thought of as a neurodegenerative disorder, there is mounting evidence that changes in glial cells occur with AD progression as well.
Functional p53 prevents the progression of cancer by mounting growth inhibition in the form of apoptosis, senescence and/or autophagy.
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