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However, a more systematic screening for miRNA binding sites and validation studies of miRNA/ MYCN-3′UTR interactions have to our knowledge not been performed.
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4 5 6 The feasibility for endoscopic treatment now means that more systematic screening for Barrett's oesophagus merits further consideration.
Therefore, more systematic screening to investigate C. albicans populations in ICUs might suggest intra-hospital acquisition and lead to reinforcement of clinical procedures.
Second, the type of information sent out to professionals invited to identify children varied from simple letters, including a few clinical descriptors of autism-related symptoms or diagnostic checklists rephrased in nontechnical terms, to more systematic screening strategy based on questionnaires or rating scales of known reliability and validity.
A more systematic virtual screening study has also been conducted to investigate the interrelation between eight fingerprinting methods, eleven atomtyping schemes, seven bit scaling rules, and four similarity metrics.
A more systematic HIV screening of pregnant women that is repeated during pregnancy among women likely to engage in risky behaviour is needed to optimise the prevention of MTCT.
Additionally, inherited variation in metabolism genes such as DPYD or CYP2D6 has been associated with 5-fluorouracil toxicity and possibly tamoxifen efficacy [ 12], respectively, and, although the variants are rare, a more systematic clinical screening would provide important benefits.
More systematic screens are needed to identify kinases and phosphatases that regulate proteasome activity and phosphorylation profile.
Advances in modern sequencing technologies, bioinformatics analysis tools, and environmental DNA cloning methods should allow for a movement in natural products discovery away from a random microbe screening approach to a more systematic sequence-based screening approach that will allow for the functional examination of gene clusters that remain hidden in the environment.
While some patients are resistant, many are supportive of a more systematic approach to screening and brief intervention.
Given that cardiovascular risk assessment has been shown to be acceptable to many people with psychosis, 36 a more systematic use of such screening in both primary and secondary care may improve early detection and treatment of hypertension, hypercholesterolaemia, diabetes and smoking.
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